@genebe/bipex

BipEx bipolar disorder case/control exome results

Per-variant case/control burden results from the Bipolar Exomes (BipEx) collaboration, restricted to the combined "Bipolar Disorder (including Schizoaffective)" analysis group, which is the most inclusive of BipEx's several published case-cohort definitions (broader than the bare "Bipolar Disorder" group, and a superset of the BD1/BD2/with-psychosis/without-psychosis subtype breakdowns).

Alternate allele frequencies af_case and af_ctrl are derived from the reported allele counts and allele numbers (ac_case / an_case and ac_ctrl / an_ctrl); they are null when the corresponding allele number is zero or unknown.

Only single-nucleotide variants on canonical chromosomes are included. Where a small number of variants collide onto the same GRCh38 position, the row with the larger combined case+control allele number is kept.

Source

BipEx: Bipolar Exomes Browser, variant_results.vcf.bgz (GRCh38), https://bipex.broadinstitute.org/downloads

Citation

Palmer DS, Howrigan DP, Chapman SB, et al. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nature Genetics. 2022;54:541-547. doi:10.1038/s41588-022-01034-x.

Website: https://bipex.broadinstitute.org/