@genebe/vesm_3b

This annotation is derived from the VESM-3B hg38 precomputed variant-effect scores. It retains the source score named VESM (3B) under vesm_3b and maps variants to SPDI keys. If multiple source rows map to one genomic allele, the minimum score is retained.

The VESM models and precomputed predictions are described in:

Dinh T, Jang S-K, Zaitlen N, Ntranos V. Compressing the collective knowledge of ESM into a single protein language model. Nature Methods. 2026;23:772–784. doi:10.1038/s41592-026-03050-9. Please cite the paper when using these scores.

The VESM score files describe predicted variant effects; the score is preserved as supplied and is not recalibrated by this builder.