CXCL6 p.Val11Ala

Variant names:

• chr4-73836782-T-C
• rs768103843
• NM_002993.4:c.32T>C
• CXCL6 p.Val11Ala

Your query was ambiguous. Multiple possible variants found:

• chr4-73836782-T-C
• chr4-73836782-TC-CA
• chr4-73836782-TC-CG
• chr4-73836782-TC-CT

GermlineCancer (beta)

Variant summary

Our verdict is Uncertain significance.

0 Uncertain · Cold

-7

-6

-1

0

+5

+6

+9

+10

BenignB

Likely BenignLB

UncertainVUS

Likely PathogenicLP

PathogenicP

The variant received 0 classification points (ACGS-UK Somatic Oncogenicity v2025). O3_SupportingB3_Supporting

The NM_002993.4(CXCL6):c.32T>C (p.Val11Ala) variant causes a missense change involving the alteration of a non-conserved nucleotide. The gene CXCL6 is a known oncogene (CancerMine: 1 oncogene citations). The variant allele was found at a cumulative frequency of 0.0000161 (AC=26) in the gnomAD database across 1,611,560 control chromosomes (no homozygotes observed). The grpmax filtering allele frequency (95% CI) is 0.0000146. In-silico predictor (REVEL) classifies this variant as likely benign. Splicing prediction tools (SpliceAI) predict no significant impact on normal splicing. Variant has been reported in ClinVar as Uncertain Significance (★).

• Frequency:
  • Genomes: 𝑓 0.000013 (0 hom., cov: 32)
  • Exomes 𝑓: 0.000016 (0 hom.)
• Consequence: CXCL6 NM_002993.4 missense
• Clinical Significance: Uncertain significance criteria provided, single submitter U:1
• Conservation: PhyloP100: -0.978
• Publications: 1 publications found

Genes affected

CXCL6 (HGNC:10643): (C-X-C motif chemokine ligand 6) The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]

ENSG00000298131 (HGNC:):

Classification according to ACGS-UK Somatic Oncogenicity v2025

Classification was made for transcript:

Our verdict: Uncertain_significance. The variant received 0 points.

Apply	Criterion Code & Title / Strength	Strength	Rationale / Clinical Context
	O3Absent or very rare in population		Very rare in gnomAD (popmax AF <0.01%) — O3 supporting; GnomAD effective popmax AF = 0.000015 — very rare (O3 supporting [+1])
	B3Computational evidence does not support deleterious effect		Computational evidence does not support a deleterious effect; Missense variant — primary computational scorer does not support an oncogenic/deleterious effect; supports B3

Variant Effect in Transcripts

Automated classification analysis was done for transcript: NM_002993.4. You can select a different transcript below to see updated classification assignments.

RefSeq Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	CXCL6 NM_002993.4	MANE Select	c.32T>C p.Val11Ala	missense	Exon 1 of 4	Prot: NP_002984.1 UniProt:

CXCL6 NM_002993.4

MANE Select

HGVSc / HGVSpc.32T>Cp.Val11Ala

Exon rankExon 1 of 4

missense

Prot: NP_002984.1UniProt: P80162

Ensembl Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	CXCL6 ENST00000226317.10	TSL:1MANE Select	c.32T>C p.Val11Ala	missense	Exon 1 of 4	Prot: ENSP00000226317.5 UniProt:
	CXCL6 ENST00000515050.1	TSL:1	c.32T>C p.Val11Ala	missense	Exon 1 of 3	Prot: ENSP00000424819.1 UniProt:
	ENSG00000298131 ENST00000753200.1		n.196A>G	non_coding_transcript_exon	Exon 1 of 1	Prot:

CXCL6 ENST00000226317.10

TSL:1MANE Select

HGVSc / HGVSpc.32T>Cp.Val11Ala

Exon rankExon 1 of 4

missense

Prot: ENSP00000226317.5UniProt: P80162

CXCL6 ENST00000515050.1

TSL:1

HGVSc / HGVSpc.32T>Cp.Val11Ala

Exon rankExon 1 of 3

missense

Prot: ENSP00000424819.1UniProt: D6RF92

ENSG00000298131 ENST00000753200.1

HGVSc / HGVSpn.196A>G

Exon rankExon 1 of 1

non_coding_transcript_exon

Prot:

Frequencies

Allele frequencies (AF), counts (AC/AN), homozygotes and coverage

Common (AF > 0.05 / Hom > 5)

Rare (AF ≤ 0.0001 / Hom ≤ 1)

Source / population	AF	AC	Hom	AN	Coverage
Global population databases 6 sources Large-scale international reference populations
GnomAD3 genomes	AF: 0.0000131	AC:2	Hom:0	AN:152142	Cov:32
GnomAD2 exomes	AF: 0.00000408	AC:1	Hom:	AN:245036	Cov:
GnomAD4 exome	AF: 0.0000164	AC:24	Hom:0	AN:1459418	Cov:32
GnomAD4 genome	AF: 0.0000131	AC:2	Hom:0	AN:152142	Cov:32
TOPMed (Bravo)	AF: 0.0000189	AC:	Hom:	AN:	Cov:
ALFA (dbGaP/dbSNP Allele Frequency Aggregator)	AF: 0.00	AC:0	Hom:0	AN:16840	Cov:

Showing 6 sources

Case/control cohorts

Cohort	Cases			Controls
	AF	AC	AN	AF	AC	AN
BipEx(Bipolar disorder (including schizoaffective))	0.000106	3	28420	0.00	0	28844
Epi25(Epilepsy)	0.0000238	1	41958	0.00	0	66888
SCHEMA(Schizophrenia)	0.00000969	1	103152	0.00	0	184166

Showing 3 cohortsAllele count / allele number. AF is computed from the counts for ASC (not provided by the source).

ClinVar

ClinVar submissions

Significance: Uncertain significance

Revision: criteria provided, single submitter

Pathogenic	VUS	Benign	Condition
-	1	-	not specified (1)

Computational Scores

Algorithm	Calibrated pred.	Score	Prediction
AlphaGenome AVI	Benign	0.90
AlphaMissense	Benign	0.11
BayesDel_addAF	Benign	-0.35	T
BayesDel_noAF	Benign	-0.74
CADD	Benign	0.59
DANN	Benign	0.40
DEOGEN2	Benign	0.045	T
Eigen	Benign	-1.5
Eigen_PC	Benign	-1.6
FATHMM_MKL	Benign	0.031	N
FuncVEP CTI	Benign	0.026
GPN-Star LLR	N/A	-1.0
GPN-Star score	N/A	1.0
LIST_S2	Benign	0.43	T
M_CAP	Benign	0.0054	T
MetaRNN	Benign	0.052	T
MetaSVM	Benign	-1.0	T
Mutation Taster	N/A	97/3	polymorphism
MutationAssessor	Benign	1.8	L
PhyloP100	Benign	-0.98
popEVE	Benign	-2.4
PrimateAI	Uncertain	0.53	T
PromoterAI	N/A	-0.0092	Neutral
PROVEAN	Benign	0.060	N
REVEL	Benign	0.036
Sift	Uncertain	0.013	D
Sift4G	Benign	0.66	T
Varity_R	N/A	0.044
VESM-3B	Benign	-1.6

Showing 29 of 29 scores

Splicing Scores

Algorithm	Calibrated pred.	Score	Prediction
Pangolin (max)	Benign	0.0
SpliceAI score (max)	Benign	0.0	Details are displayed if max score is > 0.2

Showing 2 of 2 scores

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

MaxEntScan Visualizer can be used to analyze the impact of this mutation on the neighboring sequence.

MaveDB functional evidence

MaveDB is a public repository of laboratory assays that test the effect of thousands of variants at once — treat this as supporting research data and interpret it with great caution; it is not a clinical classification.

No MaveDB functional evidence found for this variant.

Other links and lift over

dbSNP: rs768103843;

hg19: chr4-74702499;

ACMG debug oncogenicity

ACGS debug oncogenicity

ACMG debug germline

Submit to ClinVar