chr10-133185982-G-C

Variant names:

• chr10-133185982-G-C
• rs751668060
• NM_152643.8:c.634G>C

Variant summary

Our verdict is Uncertain significance. Variant got 0 ACMG points: 2P and 2B. PM2 BP4_Moderate

The NM_152643.8(KNDC1):​c.634G>C​(p.Glu212Gln) variant causes a missense change. The variant allele was found at a frequency of 0.00000138 in 1,444,150 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency:
  • Genomes: not found (cov: 29)
  • Exomes 𝑓: 0.0000014 (0 hom.)
• Consequence: KNDC1 NM_152643.8 missense
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: 5.09

Genes affected

KNDC1 (HGNC:29374): (kinase non-catalytic C-lobe domain containing 1) The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]

ACMG classification

Verdict is Uncertain_significance. Variant got 0 ACMG points.

• PM2: Very rare variant in population databases, with high coverage
• BP4: Computational evidence support a benign effect (MetaRNN=0.20447236).

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
KNDC1	NM_152643.8	c.634G>C	p.Glu212Gln	missense_variant	Exon 6 of 30	ENST00000304613.8	NP_689856.6
KNDC1	XM_017016858.3	c.634G>C	p.Glu212Gln	missense_variant	Exon 6 of 27		XP_016872347.1
KNDC1	XM_017016859.3	c.634G>C	p.Glu212Gln	missense_variant	Exon 6 of 21		XP_016872348.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
KNDC1	ENST00000304613.8	c.634G>C	p.Glu212Gln	missense_variant	Exon 6 of 30	1	NM_152643.8	ENSP00000304437.3

Frequencies

GnomAD3 genomes Cov.: 29

GnomAD3 exomes AF: 0.00000478 AC: 1 AN: 209382 Hom.: 0 AF XY: 0.00000873 AC XY: 1 AN XY: 114594

Gnomad AFR exome AF: 0.00

Gnomad AMR exome AF: 0.00

Gnomad ASJ exome AF: 0.00

Gnomad EAS exome AF: 0.0000612

Gnomad SAS exome AF: 0.00

Gnomad FIN exome AF: 0.00

Gnomad NFE exome AF: 0.00

Gnomad OTH exome AF: 0.00

GnomAD4 exome AF: 0.00000138 AC: 2 AN: 1444150 Hom.: 0 Cov.: 35 AF XY: 0.00000140 AC XY: 1 AN XY: 716582

Gnomad4 AFR exome AF: 0.00

Gnomad4 AMR exome AF: 0.00

Gnomad4 ASJ exome AF: 0.00

Gnomad4 EAS exome AF: 0.0000256

Gnomad4 SAS exome AF: 0.00

Gnomad4 FIN exome AF: 0.00

Gnomad4 NFE exome AF: 9.05e-7

Gnomad4 OTH exome AF: 0.00

GnomAD4 genome Cov.: 29

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Benign	0.15
BayesDel_addAF	Benign	-0.30	T
BayesDel_noAF	Benign	-0.48
CADD	Benign	22
DANN	Uncertain	1.0
DEOGEN2	Benign	0.072	T;.
Eigen	Benign	0.062
Eigen_PC	Benign	-0.060
FATHMM_MKL	Benign	0.63	D
LIST_S2	Benign	0.59	T;T
M_CAP	Benign	0.015	T
MetaRNN	Benign	0.20	T;T
MetaSVM	Benign	-1.1	T
PrimateAI	Uncertain	0.60	T
PROVEAN	Benign	-1.5	N;N
REVEL	Benign	0.047
Sift	Uncertain	0.0090	D;T
Sift4G	Benign	0.065	T;T
Polyphen		0.98	D;D
Vest4		0.23
MutPred		0.20		Gain of helix (P = 6e-04);.;
MVP		0.25
MPC		0.68
ClinPred		0.59	D
GERP RS		4.0
Varity_R		0.24
gMVP		0.40

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

LitVar

Other links and lift over

dbSNP: rs751668060; hg19: chr10-134999486; COSMIC: COSV105169337;