chr10-88453705-C-T

Position:

• chr10-88453705-C-T

Variant summary

Our verdict is Benign. Variant got -12 ACMG points: 0P and 12B. BP4_Strong BA1

The ENST00000331772.9(RNLS):​c.527-90980G>A variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.186 in 152,154 control chromosomes in the GnomAD database, including 3,028 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency: Genomes: 𝑓 0.19 (3028 hom., cov: 33)
• Consequence: RNLS ENST00000331772.9 intron
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -0.660

Genes affected

RNLS (HGNC:25641): (renalase, FAD dependent amine oxidase) Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Apr 2022]

ACMG classification

Verdict is Benign. Variant got -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.93).
• BA1: GnomAd4 highest subpopulation (NFE) allele frequency at 95% confidence interval = 0.252 is higher than 0.05.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	MANE	Protein	UniProt
RNLS	NM_001031709.3	c.527-90980G>A		intron_variant		ENST00000331772.9	NP_001026879.2

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	TSL	MANE	Protein	Appris	UniProt
RNLS	ENST00000331772.9	c.527-90980G>A		intron_variant		1	NM_001031709.3	ENSP00000332530	P1
RNLS	ENST00000371947.7	c.527-90980G>A		intron_variant		2		ENSP00000361015
RNLS	ENST00000466945.5	n.510-90980G>A		intron_variant, non_coding_transcript_variant		3
RNLS	ENST00000481793.1	n.418-90980G>A		intron_variant, non_coding_transcript_variant		2

Frequencies

GnomAD3 genomes AF: 0.186 AC: 28311 AN: 152036 Hom.: 3027 Cov.: 33

Gnomad AFR AF: 0.117

Gnomad AMI AF: 0.257

Gnomad AMR AF: 0.159

Gnomad ASJ AF: 0.128

Gnomad EAS AF: 0.00385

Gnomad SAS AF: 0.0662

Gnomad FIN AF: 0.213

Gnomad MID AF: 0.104

Gnomad NFE AF: 0.255

Gnomad OTH AF: 0.181

We have no GnomAD4 exomes data on this position. Probably position not covered by the project.

GnomAD4 genome AF: 0.186 AC: 28324 AN: 152154 Hom.: 3028 Cov.: 33 AF XY: 0.180 AC XY: 13416 AN XY: 74374

Gnomad4 AFR AF: 0.117

Gnomad4 AMR AF: 0.159

Gnomad4 ASJ AF: 0.128

Gnomad4 EAS AF: 0.00386

Gnomad4 SAS AF: 0.0659

Gnomad4 FIN AF: 0.213

Gnomad4 NFE AF: 0.255

Gnomad4 OTH AF: 0.179

Alfa AF: 0.204 Hom.: 568

Bravo AF: 0.180

Asia WGS AF: 0.0470 AC: 163 AN: 3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.93
CADD	Benign	3.3
DANN	Benign	0.44

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

LitVar

Other links and lift over

dbSNP: rs10509548; hg19: chr10-90213462;