rs2295879
Variant summary
Our verdict is Benign. Variant got -12 ACMG points: 0P and 12B. BP4_StrongBA1
The NM_206862.4(TACC2):c.8194G>A(p.Ala2732Thr) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.307 in 1,613,346 control chromosomes in the GnomAD database, including 78,327 homozygotes. In-silico tool predicts a benign outcome for this variant. 14/20 in silico tools predict a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar. Another nucleotide change resulting in the same amino acid substitution has been previously reported as Likely benign in UniProt.
Frequency
Consequence
NM_206862.4 missense
Scores
Clinical Significance
Conservation
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ACMG classification
Verdict is Benign. Variant got -12 ACMG points.
Transcripts
RefSeq
Ensembl
Frequencies
GnomAD3 genomes AF: 0.269 AC: 40877AN: 151872Hom.: 5923 Cov.: 32
GnomAD3 exomes AF: 0.307 AC: 77115AN: 251042Hom.: 12410 AF XY: 0.314 AC XY: 42603AN XY: 135676
GnomAD4 exome AF: 0.311 AC: 454846AN: 1461356Hom.: 72389 Cov.: 38 AF XY: 0.315 AC XY: 228710AN XY: 726968
GnomAD4 genome AF: 0.269 AC: 40909AN: 151990Hom.: 5938 Cov.: 32 AF XY: 0.271 AC XY: 20150AN XY: 74284
ClinVar
Not reported inComputational scores
Source:
Splicing
Find out detailed SpliceAI scores and Pangolin per-transcript scores at